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Article

Optimization of gene expression by natural selection.

Proceedings of the National Academy of Sciences of the United States of America - 27 Jan 2009

Bedford Trevor, Hartl Daniel L

Abstract excerpt

It is generally assumed that stabilizing selection promoting a phenotypic optimum acts to shape variation in quantitative traits across individuals and species. Although gene expression represents an intensively studied molecular phenotype, the extent to which stabilizing selection limits divergence in gene expression remains contentious. In this study, we present a theoretical framework for the study of...

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Identifiers

PMID: 19139403
DOI: 10.1073/pnas.0812009106
PMCID: PMC2633540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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