Article
Angiotensin-converting enzyme gene polymorphism in arrhythmogenic right ventricular dysplasia: is DD genotype helpful in predicting syncope risk?
Journal of the renin-angiotensin-aldosterone system : JRAAS - 1 Dec 2008
Ozben Beste, Altun Ibrahim, Sabri Hancer Veysel, Bilge Ahmet Kaya, Tanrikulu Azra Meryem, Diz-Kucukkaya Reyhan, Fak Ali Serdar, Yilmaz Ercument, Adalet Kamil
Abstract excerpt
INTRODUCTION: Arrhythmogenic right ventricular dysplasia (ARVD) is a heritable disorder characterised by fibrofatty replacement of right ventricular myocytes and increased risk of ventricular arrhythmias and sudden cardiac death. Angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism affects myocardial ACE levels. DD genotype favours myocardial fibrosis and is associated with malignant...
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