Article
Linkage analysis of high myopia susceptibility locus in 26 families.
Molecular vision - 1 Jan 2008
Paget Sandrine, Julia Sophie, Vitezica Zulma G, Soler Vincent, Malecaze François, Calvas Patrick
Abstract excerpt
PURPOSE: We conducted a linkage analysis in high myopia families to replicate suggestive results from chromosome 7q36 using a model of autosomal dominant inheritance and genetic heterogeneity. We also performed a genome-wide scan to identify novel loci. METHODS: Twenty-six families, with at least two high-myopic subjects (ie. refractive value in the less affected eye of -5 diopters) in each family, were included....
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