Article
Ethnic differences in F cell levels in Jamaica: a potential tool for identifying new genetic loci controlling fetal haemoglobin.
British journal of haematology - 1 Mar 2009
Creary Lisa E, McKenzie Colin A, Menzel Stephan, Hanchard Neil A, Taylor Veronica, Hambleton Ian, Spector Tim D, Forrester Terrence E, Thein Swee Lay
Abstract excerpt
High levels of fetal haemoglobin (HbF) are protective in beta-haemoglobinopathies. The proportion of erythrocytes containing HbF (F-cells, FC) was measured in healthy adults of African and Caucasian ancestry to assess the feasibility of localizing genes for the FC trait using admixture mapping. Participants were Afro-Caribbean (AC) blood donors and residents of a rural enclave with a history of recent German...
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