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Article

High efficacy of beta-blockers in long-QT syndrome type 1: contribution of noncompliance and QT-prolonging drugs to the occurrence of beta-blocker treatment "failures".

Circulation - 20 Jan 2009

Vincent G Michael, Schwartz Peter J, Denjoy Isabelle, Swan Heikki, Bithell Candice, Spazzolini Carla, Crotti Lia, Piippo Kirsi, Lupoglazoff Jean-Marc, Villain Elizabeth, Priori Silvia G, Napolitano Carlo, Zhang Li

Abstract excerpt

BACKGROUND: Beta-blocker efficacy in long-QT syndrome type 1 is good but variably reported, and the causes of cardiac events despite beta-blocker therapy have not been ascertained. METHODS AND RESULTS: This was a retrospective study of the details surrounding cardiac events in 216 genotyped long-QT syndrome type 1 patients treated with beta-blocker and followed up for a median time of 10 years. Before...

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Identifiers

PMID: 19118258
DOI: 10.1161/CIRCULATIONAHA.108.772533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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