Article
Interaction between variant apolipoproteins C-II and E that affects plasma lipoprotein concentrations.
Arteriosclerosis and thrombosis : a journal of vascular biology - 1 Jan 2000
Hegele R A, Breckenridge W C, Cox D W, Maguire G F, Little J A, Connelly P W
Abstract excerpt
The genes for apolipoprotein (apo) C-II, a cofactor for activation of lipoprotein lipase, and apo E, a ligand for receptor-mediated uptake of triglyceride-rich lipoproteins, are physically linked on chromosome 19q13.1. In a large Caribbean Caucasian family, several individuals had clinical features of the complete absence of lipoprotein lipase activity and were homozygous for a DNA frameshift mutation of apo...
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