Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins.

Journal of cellular physiology - 1 May 2009

Bae Yong Ho, Ding Zhijie, Zou Li, Wells Alan, Gertler Frank, Roy Partha

Abstract excerpt

We previously showed that silencing profilin-1 (Pfn1) expression increases breast cancer cell motility, but the underlying mechanisms have not been explored. Herein, we demonstrate that loss of Pfn1 expression leads to slower but more stable lamellipodial protrusion thereby enhancing the net prot...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Cell Adhesion Molecules
Share to Gene Silencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microfilament Proteins

Share to Phosphoproteins

Share to Profilins

Share to Pseudopodia

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 19115233
DOI: 10.1002/jcp.21677
PMCID: PMC2990882

Genes

VASP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19115233-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins.PMID 19115233Read ↗

Actin Filaments at the Leading Edge of Cancer Cells Are Characterized by a High Mobile Fraction and Turnover Regulation by Profilin ISemantic proximity Read ↗

Profilin-1 Overexpression in MDA-MB-231 Breast Cancer Cells Is Associated with Alterations in Proteomics Biomarkers of Cell Proliferation, Survival, and Motility as Revealed by Global Proteomics AnalysesSemantic proximity Read ↗

A High-Content, Multiplexed Screen in Human Breast Cancer Cells Identifies Profilin-1 Inducers with Anti-Migratory ActivitiesSemantic proximity Read ↗

Looking over the edge: a new role for Ena/VASP proteins in lamellipodial dynamics.Semantic proximity Read ↗

alpha4beta1 integrin regulates lamellipodia protrusion via a focal complex/focal adhesion-independent mechanism.Semantic proximity Read ↗

Bulky glycocalyx drives cancer invasiveness by modulating substrate-specific adhesionSemantic proximity Read ↗

Characterization of the role of RILP in cell migration.Semantic proximity Read ↗

Phosphatidylinositol 4-kinase III beta regulates cell shape, migration and Focal Adhesion numberSemantic proximity Read ↗

The calcium pump PMCA4b promotes epithelial cell polarization and lumen formationSemantic proximity Read ↗

Cyclin D1/Cyclin-Dependent Kinase 4 Interacts with Filamin A and Affects the Migration and Invasion Potential of Breast Cancer CellsSemantic proximity Read ↗

EVL (Ena/VASP-like) expression is up-regulated in human breast cancer and its relative expression level is correlated with clinical stagesSemantic proximity Read ↗

Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.