Article
Reduced proliferative activity of primary POMGnT1-null myoblasts in vitro.
Mechanisms of development - 1 Jan 2000
Miyagoe-Suzuki Yuko, Masubuchi Nami, Miyamoto Kaori, Wada Michiko R, Yuasa Shigeki, Saito Fumiaki, Matsumura Kiichiro, Kanesaki Hironori, Kudo Akira, Manya Hiroshi, Endo Tamao, Takeda Shin'ichi
Abstract excerpt
Protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase 1 (POMGnT1) is an enzyme that transfers N-acetylglucosamine to O-mannose of glycoproteins. Mutations of the POMGnT1 gene cause muscle-eye-brain (MEB) disease. To obtain a better understanding of the pathogenesis of MEB disease, we mutated the POMGnT1 gene in mice using a targeting technique. The mutant muscle showed aberrant glycosylation of...
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