Article
Unique transgenic animal model for hereditary hearing loss.
The Annals of otology, rhinology, and laryngology - 1 Nov 2008
Cosetti Maura, Culang David, Kotla Sumankrishna, O'Brien Peter, Eberl Daniel F, Hannan Frances
Abstract excerpt
OBJECTIVES: This study capitalizes on the unique molecular and developmental similarities between the auditory organs of Drosophila and mammals, to investigate genes implicated in human syndromic and nonsyndromic hearing loss in a genetically tractable experimental animal model, the fruit fly Drosophila. METHODS: The Drosophila counterparts of 3 human deafness genes (DIAPH1/DFNA1, ESPN/DFNB36, and TMHS/DF-NB67)...
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