Article
Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer
1 Dec 2008
Abstract excerpt
BACKGROUND: Enhanced activity of histone deacetylases (HDAC) is associated with more aggressive tumour behaviour and tumour progression in various solid tumours. The over-expression of these proteins and their known functions in malignant neoplasms has led to the development of HDAC inhibitors (HDI) as new anti-neoplastic drugs. However, little is known about HDAC expression in renal cell cancer. METHODS: We...
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