Article
Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1.
Nature genetics - 1 Jan 2009
Ligtenberg Marjolijn J L, Kuiper Roland P, Chan Tsun Leung, Goossens Monique, Hebeda Konnie M, Voorendt Marsha, Lee Tracy Y H, Bodmer Danielle, Hoenselaar Eveline, Hendriks-Cornelissen Sandra J B, Tsui Wai Yin, Kong Chi Kwan, Brunner Han G, van Kessel Ad Geurts, Yuen Siu Tsan, van Krieken J Han J M, Leung Suet Yi, Hoogerbrugge Nicoline
Abstract excerpt
Lynch syndrome patients are susceptible to colorectal and endometrial cancers owing to inactivating germline mutations in mismatch repair genes, including MSH2 (ref. 1). Here we describe patients from Dutch and Chinese families with MSH2-deficient tumors carrying heterozygous germline deletions o...
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