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Article

Synergistic effects of mutations and nanoparticle templating in the self-assembly of cowpea chlorotic mottle virus capsids.

Nano letters - 1 Jan 2009

Aniagyei Stella E, Kennedy Chelsea J, Stein Barry, Willits Deborah A, Douglas Trevor, Young Mark J, De Mrinmoy, Rotello Vincent M, Srisathiyanarayanan D, Kao C Cheng, Dragnea Bogdan

Abstract excerpt

A study of the in vitro nanoparticle-templated assembly of a mutant of cowpea chlorotic mottle virus lacking most of the N-terminal domain (residues 4-37), NDelta34, is presented. Mutant empty proteins assemble into empty capsids with a much broader distribution of sizes than the wild-type virus. This increased flexibility in the assembly outcomes is known to be detrimental for the assembly process in the...

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Identifiers

PMID: 19090695
DOI: 10.1021/nl8032476
PMCID: PMC2753382

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