Article
The association of Apoprotein E polymorphisms with recurrent pregnancy loss.
American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Jan 2009
Goodman Chelsi, Goodman Cyle S, Hur Jee, Jeyendran R S, Coulam Carolyn
Abstract excerpt
PROBLEM: We have previously reported the role of polymorphisms of thrombogenic genes involved in coagulation and fibrinolysis as risk factors for recurrent pregnancy loss. Thrombophilia has been viewed as a multigenic disorder rather than a monogenetic clinical phenotype and Apo E has been shown to play an important role in lipid metabolism in pregnancy. As individuals carrying the E4 allele of the ApoE gene have...
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