Article
Normal dopaminergic nigrostriatal innervation in SPG3A hereditary spastic paraplegia.
Journal of neurogenetics - 1 Jan 2008
Albin Roger L, Koeppe Robert A, Rainier Shirley, Fink John K
Abstract excerpt
SPG3A/atlastin-1 gene mutations cause an autosomal dominant form of hereditary spastic paraplegia (SPG3A-HSP). We used positron emission tomography with [(11)C]DTBZ to assess nigrostriatal dopaminergic integrity in two unrelated adults with SPG3A-HSP due to the common SPG3A/atlastin-1 mutation, R...
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