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Article

SPG11‐related parkinsonism: Clinical profile, molecular imaging and l ‐dopa response

1 Oct 2018

Abstract excerpt

BACKGROUND: Molecular imaging has proven to be a powerful tool to elucidate degenerated paths in a wide variety of neurological diseases and has not been systematically studied in hereditary spastic paraplegias. OBJECTIVES: To investigate dopaminergic degeneration in a cohort of 22 patients with hereditary spastic paraplegia attributed to SPG11 mutations and evaluate treatment response to l-dopa. METHODS:...

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PMID: 30306626
DOI: 10.1002/mds.27491

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