Article
Comparison of arachidonate metabolism by alveolar macrophages from bighorn and domestic sheep.
Inflammation - 1 Feb 1991
Silflow R M, Foreyt W J, Taylor S M, Laegreid W W, Liggitt H D, Leid R W
Abstract excerpt
We have defined the metabolites of arachidonic acid (AA) secreted by alveolar macrophages (AMs) of bighorn sheep and domestic sheep in response to three agents: calcium ionophore A23187, phorbol myristate acetate (PMA), and opsonized zymosan. Cells were labeled with [3H]AA prior to stimulation and 11 tritiated metabolites, including prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and...
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