Article
Prenatal diagnosis of Huntington disease in maternal plasma: direct and indirect study.
European journal of neurology - 1 Dec 2008
Bustamante-Aragones A, Trujillo-Tiebas M J, Gallego-Merlo J, Rodriguez de Alba M, Gonzalez-Gonzalez C, Cantalapiedra D, Ayuso C, Ramos C
Abstract excerpt
BACKGROUND AND PURPOSE: The presence of cell-free fetal DNA in maternal plasma could allow performing a non-invasive prenatal diagnosis of Huntington disease (HD). The great advantage of this diagnosis is the absence of risk of fetal loss that it entails. METHODS: Maternal plasma from four pregnant women in their first trimester of gestation with a fetus at-risk was studied. In all the four cases, the father was...
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