Article
Gene expression profiling: canonical molecular changes and clinicopathological features in sporadic colorectal cancers.
World journal of gastroenterology - 21 Nov 2008
Kim Jin-Cheon, Kim Seon-Young, Roh Seon-Ae, Cho Dong-Hyung, Kim Dae-Dong, Kim Jeong-Hyun, Kim Yong-Sung
Abstract excerpt
AIM: To investigate alternative or subordinate pathways involved in colorectal tumorigenesis and tumor growth, possibly determining at-risk populations and predicting responses to treatment. METHODS: Using microarray gene-expression analysis, we analyzed patterns of gene expression relative to canonical molecular changes and clinicopathological features in 84 sporadic colorectal cancer patients, standardized by...
Topics
- Cell Proliferation
- Colorectal Neoplasms
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Genes, APC
- Genes, p53
- Genetic Predisposition to Disease
- Humans
- Mutation
- Oligonucleotide Array Sequence Analysis
- Prospective Studies
- Retrospective Studies