Article
Vitamin D receptor gene polymorphisms predict acquired resistance to clodronate treatment in patients with Paget's disease of bone.
Calcified tissue international - 1 Dec 2008
Mossetti Giuseppe, Gennari Luigi, Rendina Domenico, De Filippo Gianpaolo, Merlotti Daniela, De Paola Vincenzo, Fusco Pina, Esposito Teresa, Gianfrancesco Fernando, Martini Giuseppe, Nuti Ranuccio, Strazzullo Pasquale
Abstract excerpt
Bisphosphonates are first-choice drugs for treatment of Paget's disease of bone (PDB); nevertheless, acquired resistance to bisphosphonate therapy has been described in PDB patients. The 1,25(OH)(2)D(3)/vitamin D receptor (VDR) system influences the effectiveness of antiresorptive treatments in metabolic bone disorders. This study evaluated the relationship between acquired resistance to clodronate treatment and...
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