Article
No evidence for shared etiology in two demyelinative disorders, MS and PLOSL.
Journal of neuroimmunology - 3 Jan 2009
Sulonen Anna-Maija, Kallio Suvi P, Ellonen Pekka, Suvela Minna, Elovaara Irina, Koivisto Keijo, Pirttilä Tuula, Reunanen Mauri, Tienari Pentti J, Palotie Aarno, Peltonen Leena, Saarela Janna
Abstract excerpt
Loss-of-function mutations of DAP12 and TREM2 cause a recessively inherited disease PLOSL, manifesting in brain white matter. The genes of the DAP12-TREM2 signaling receptor are located on 19q13.12 and 6p21.1, to which linkage has been observed also in families affected by another immune-mediated demyelinating disease, MS. We have tested if allelic variation in DAP12 or TREM2 predisposes also to MS by monitoring...
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