Article
Angiotensin-converting enzyme genotype and encephalopathy in Chernobyl cleanup workers.
European journal of neurology - 1 Jan 2009
Kehoe A D, Nikiforov A M, Alexanin S S, Neronov E G, Tikhomirova O V, Shun'kov V B, Makarova N V, Rabinovich E, Usmanova N M, Kazakov V I, Slozina N M, Montgomery H E
Abstract excerpt
BACKGROUND AND PURPOSE: To identify, using a genetic model, a key role for the renin-angiotensin system (RAS) in the development of dyscirculatory encephalopathy (DE) in Chernobyl cleanup workers (CCW). The insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene denotes a substantial individual variation in RAS activity with the D-allele being associated with higher ACE activity. METHODS:...
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