Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing.

PLoS biology - 18 Nov 2008

Dethlefsen Les, Huse Sue, Sogin Mitchell L, Relman David A

Abstract excerpt

The human intestinal microbiota is essential to the health of the host and plays a role in nutrition, development, metabolism, pathogen resistance, and regulation of immune responses. Antibiotics may disrupt these coevolved interactions, leading to acute or chronic disease in some individuals. Our understanding of antibiotic-associated disturbance of the microbiota has been limited by the poor sensitivity,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteria
Share to Ciprofloxacin
Share to Feces

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gastrointestinal Tract

Share to Intestines

Share to Principal Component Analysis

Share to RNA, Bacterial

Share to RNA, Ribosomal, 16S

Source

Open in PubMed Open full text

Identifiers

PMID: 19018661
DOI: 10.1371/journal.pbio.0060280
PMCID: PMC2586385

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing.PMID 19018661Read ↗

Understanding the impact of antibiotic perturbation on the human microbiomeSemantic proximity Read ↗

Ecological and Evolutionary responses to Antibiotic Treatment in the Human Gut MicrobiotaSemantic proximity Read ↗

Acute and persistent effects of commonly used antibiotics on the gut microbiome and resistome in healthy adultsSemantic proximity Read ↗

Differential Effects of Antibiotic Therapy on the Structure and Function of Human Gut MicrobiotaSemantic proximity Read ↗

Antibiotics as both friends and foes of the human gut microbiome: The microbial community approachSemantic proximity Read ↗

Gut microbiota response to antibiotics is personalized and depends on baseline microbiotaSemantic proximity Read ↗

Antibiotics and the gut microbiotaSemantic proximity Read ↗

Effects of Antibiotics on Human Microbiota and Subsequent DiseaseSemantic proximity Read ↗

Prolonged Antibiotic Treatment Generates a Fluoroquinolone Resistant Gut Microbiome and Collateral Multi-Drug ResistanceSemantic proximity Read ↗

Antibiotic Treatment Drives the Diversification of the Human Gut ResistomeSemantic proximity Read ↗

Antibiotic Treatment Drives the Diversification of the Human Gut ResistomeSemantic proximity Read ↗

Short-Term Effect of Antibiotics on Human Gut MicrobiotaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.