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The role of quorum sensing in chronic cystic fibrosis Pseudomonas aeruginosa infections

11 Nov 2008

Abstract excerpt

Studies on cultured cells and in infection models have shown that cell density-dependent quorum-sensing (QS) controls many of the known virulence factors of Pseudomonas aeruginosa. However, it is less clear what role QS plays in chronic human lung infections associated with cystic fibrosis (CF). The involvement of QS in biofilm development, crucial to the establishment of long-term infections, suggests a role in...

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PMID: 19016870
DOI: 10.1111/j.1574-6968.2008.01394.x

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