Article
Phenotypic and enzymatic comparative analysis of the novel KPC variant KPC-5 and its evolutionary variants, KPC-2 and KPC-4.
Antimicrobial agents and chemotherapy - 1 Feb 2009
Wolter Daniel J, Kurpiel Philip M, Woodford Neil, Palepou Marie-France I, Goering Richard V, Hanson Nancy D
Abstract excerpt
A novel Klebsiella pneumoniae carbapenemase (KPC) variant, designated bla(KPC-5), was discovered in a carbapenem-resistant Pseudomonas aeruginosa clinical isolate from Puerto Rico. Characterization of the upstream region of bla(KPC-5) showed significant differences from the flanking regions of other bla(KPC) variants. Comparison of amino acid sequences with those of other KPC enzymes revealed that KPC-5 was an...
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