Article
Interferon-inducible guanylate binding protein (GBP)-2: a novel p53-regulated tumor marker in esophageal squamous cell carcinomas.
International journal of cancer - 15 Jan 2009
Guimarães Denise P, Oliveira Ivanir M, de Moraes Emanuela, Paiva Geisilene R, Souza Daniel M, Barnas Christoph, Olmedo Daniele B, Pinto Carlos E, Faria Paulo A, De Moura Gallo Claudia Vitoria, Small Isabele A, Ferreira Carlos G, Hainaut Pierre
Abstract excerpt
TP53 mutations are common in esophageal squamous cell carcinomas (SCC). To identify biological markers of possible relevance in esophageal SCC, we (i) searched for genes expressed in a p53-dependent manner in TE-1, an esophageal SCC cell line expressing the temperature-sensitive TP53 mutant V272M, and (ii) investigated the expression of one of those genes, the interferon-inducible Guanylate Binding Protein 2...
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