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Article

Identification of an interferon-gamma-responsive element of a class II major histocompatibility gene in rat type 1 astrocytes.

Journal of neuroimmunology - 1 Mar 1991

Moses H, Sasaki A, Ting J P

Abstract excerpt

Interferon-gamma(IFN-gamma) has been shown to induce class II major histocompatibility complex (MHC) antigens on several cell types. Previous analysis of cell lines including a glioblastoma multiforme line by our laboratory has mapped an IFN-gamma-responsive element to the upstream - 141 to - 109 base pair (bp) region of the DRA promoter. Using deletion mutants, this report shows that this same general region...

Topics

Animals
Astrocytes
Chloramphenicol O-Acetyltransferase
Gene Expression Regulation
Glioma
HLA-DR Antigens
Interferon-gamma
Mutation
Promoter Regions, Genetic
Rats
Rats, Inbred Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1899871
DOI: 10.1016/0165-5728(91)90049-d

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1899871-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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