Article
The measurement of the lactonase activity of paraoxonase-1 in the clinical evaluation of patients with chronic liver impairment.
Clinical biochemistry - 1 Jan 2009
Marsillach Judit, Aragonès Gerard, Beltrán Raul, Caballeria Joan, Pedro-Botet Juan, Morcillo-Suárez Carlos, Navarro Arcadi, Joven Jorge, Camps Jordi
Abstract excerpt
AIMS: We investigated the analytical performance of a new assay of the lactonase activity of paraoxonase-1 and its efficacy in the assessment of liver damage. DESIGN AND METHODS: Serum lactonase activity was determined by the hydrolysis of 5-thiobutyl butyrolactone in 633 healthy individuals and 369 patients with chronic liver disease. Paraoxonase-1, 2, and 3 gene polymorphisms were analyzed by the MassArray...
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