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Article

Complex extracellular interactions of proteases and a protease inhibitor influence multicellular development of Streptomyces coelicolor.

Molecular microbiology - 1 Dec 2008

Kim Dae Wi, Hesketh Andy, Kim Eun Sook, Song Ju Yeon, Lee Dae Hoon, Kim In Seop, Chater Keith F, Lee Kye Joon

Abstract excerpt

Streptomyces coelicolor produces an extracellular protease inhibitor protein, STI (Streptomyces trypsin inhibitor). We show that post-growth elimination of STI is needed for colonies to develop aerial mycelium efficiently. Inactivation of STI, and thus the normal progression of colony development, at least partly involves an extracellular protease specified by gene SCO5913. Two-hybrid analysis identified two...

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Source

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PMID: 18976279
DOI: 10.1111/j.1365-2958.2008.06471.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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