Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cerebral toxoplasmosis in a middle-aged man as first presentation of primary immunodeficiency due to a hypomorphic mutation in the CD40 ligand gene.

Journal of clinical pathology - 1 Nov 2008

Yong P F K, Post F A, Gilmour K C, Grosse-Kreul D, King A, Easterbrook P, Ibrahim M A A

Abstract excerpt

Cerebral toxoplasmosis can occur outside the setting of advanced HIV immunodeficiency or drug-induced immunosuppression. A case of cerebral toxoplasmosis is reported in a previously healthy 41-year-old man who was found to have a genetic defect in CD40 ligand, resulting in the X linked hyper-IgM syndrome despite normal surface protein expression on flow cytometry. This highlights the fact that primary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD40 Ligand
Share to Magnetic Resonance Imaging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Opportunistic Infections

Source

Identifiers

PMID: 18955577
DOI: 10.1136/jcp.2008.058362

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cerebral toxoplasmosis in a middle-aged man as first presentation of primary immunodeficiency due to a hypomorphic mutation in the CD40 ligand gene.PMID 18955577Read ↗

Pitfalls of "hyper"-IgM syndrome: a new CD40 ligand mutation in the presence of low IgM levels. A case report and a critical review of the literature.Semantic proximity Read ↗

Progressive choreodystonia in X-linked hyper-IgM immunodeficiency: a rare but recurrent presentation.Semantic proximity Read ↗

Phenotypic heterogeneity in a family with a CD40 ligand intracellular domain mutation.Semantic proximity Read ↗

Molecular Diagnostic Challenges and Complex Management of Consecutive Twin Pregnancies in a Family with CD40 Ligand Deficiency.Semantic proximity Read ↗

Diagnosis of Hyper IgM syndrome in a Previously Healthy Adolescent Boy Presented with Cutaneous and Cerebral Cryptococcosis.Semantic proximity Read ↗

X-linked hyper IgM syndrome: a novel sequence variant associated with an atypical mild phenotype.Semantic proximity Read ↗

Expanding the clinical and genetic spectrum of human CD40L deficiency: the occurrence of paracoccidioidomycosis and other unusual infections in Brazilian patients.Semantic proximity Read ↗

Mutations of CD40 ligand in two patients with hyper-IgM syndrome.Semantic proximity Read ↗

X-linked Hyper IgM Syndrome Presenting as Pulmonary Alveolar Proteinosis.Semantic proximity Read ↗

Case Report: Hyper IgM Syndrome Identified by Whole Genome Sequencing in a Young Syrian Man Presenting With Atypical, Severe and Recurrent Mucosal Leishmaniasis.Semantic proximity Read ↗

CD40 ligand deficiency: treatment strategies and novel therapeutic perspectivesSemantic proximity Read ↗

Enteroviral meningoencephalitis as a complication of X-linked hyper IgM syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.