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Article

Intranasal delivery of insulin and a nitric oxide synthase inhibitor in an experimental model of amyotrophic lateral sclerosis.

Neuroscience - 10 Dec 2008

Martinez J A, Francis G J, Liu W Q, Pradzinsky N, Fine J, Wilson M, Hanson L R, Frey W H, Zochodne D, Gordon T, Toth C

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disorder in which motor neurons may be targeted by oxidative and nitrergic stress without sufficient compensation by intrinsic support mechanisms. In this work, we addressed two key tenets of this hypothesis for the pathogenesis of ALS. Using superoxide dismutase (SOD) 1G93A mice, we studied the impact of reduction of nitrergic stress within the CNS...

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Identifiers

PMID: 18951954
DOI: 10.1016/j.neuroscience.2008.08.073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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