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Article

Naringin-induced p21WAF1-mediated G(1)-phase cell cycle arrest via activation of the Ras/Raf/ERK signaling pathway in vascular smooth muscle cells.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Dec 2008

Lee Eo-Jin, Moon Gi-Seong, Choi Won-Seok, Kim Wun-Jae, Moon Sung-Kwon

Abstract excerpt

The flavonoid naringin has been shown to play a role in preventing the development of cardiovascular disease. However, the exact molecular mechanisms underlying the roles of integrated cell cycle regulation and MAPK signaling pathways in the regulation of naringin-induced inhibition of cell proli...

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Source

Identifiers

PMID: 18951945
DOI: 10.1016/j.fct.2008.10.002

Genes

CDK2
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18951945-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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