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Article

Development of a Single Vector System that Enhances Trans-Splicing of SMN2 Transcripts

21 Oct 2008

Abstract excerpt

RNA modalities are developing as a powerful means to re-direct pathogenic pre-mRNA splicing events. Improving the efficiency of these molecules in vivo is critical as they move towards clinical applications. Spinal muscular atrophy (SMA) is caused by loss of SMN1. A nearly identical copy gene called SMN2 produces low levels of functional protein due to alternative splicing. We previously reported a trans-splicing...

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PMID: 18941511
DOI: 10.1371/journal.pone.0003468

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Development of a Single Vector System that Enhances Trans-Splicing of SMN2 TranscriptsPMID 18941511Read ↗

Restoration of SMN Function: Delivery of a Trans-splicing RNA Re-directs SMN2 Pre-mRNA SplicingSemantic proximity Read ↗

<i>Trans</i>-Splicing-Mediated Improvement in a Severe Mouse Model of Spinal Muscular AtrophySemantic proximity Read ↗

Stimulating Full-Length SMN2 Expression by Delivering Bifunctional RNAs via a Viral VectorSemantic proximity Read ↗

Combination of SMN <i>Trans</i> -Splicing and a Neurotrophic Factor Increases the Life Span and Body Mass in a Severe Model of Spinal Muscular AtrophySemantic proximity Read ↗

Bifunctional RNAs Targeting the Intronic Splicing Silencer N1 Increase SMN Levels and Reduce Disease Severity in an Animal Model of Spinal Muscular AtrophySemantic proximity Read ↗

Targeting the 5′ untranslated region of SMN2 as a therapeutic strategy for spinal muscular atrophySemantic proximity Read ↗

Spinal Muscular Atrophy: SMN2 Pre-mRNA Splicing Corrected by a U7 snRNA Derivative Carrying a Splicing Enhancer SequenceSemantic proximity Read ↗

Delivery of bifunctional RNAs that target an intronic repressor and increase SMN levels in an animal model of spinal muscular atrophySemantic proximity Read ↗

Bifunctional antisense oligonucleotides provide a trans-acting splicing enhancer that stimulates <i>SMN2</i> gene expression in patient fibroblastsSemantic proximity Read ↗

Restoration of Full-Length SMN Promoted by Adenoviral Vectors Expressing RNA Antisense Oligonucleotides Embedded in U7 snRNAsSemantic proximity Read ↗

A Negatively Acting Bifunctional RNA Increases <i>Survival Motor Neuron</i> Both <i>In Vitro</i> and <i>In Vivo</i>Semantic proximity Read ↗

Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophySemantic proximity Read ↗

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