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Article

Hypertension-associated kidney disease: perhaps no more.

Journal of the American Society of Nephrology : JASN - 1 Nov 2008

Freedman Barry I, Sedor John R

Abstract excerpt

Despite common wisdom, the role of essential hypertension in the etiopathogenesis of ESRD has been controversial. Two recently published studies demonstrated a strong association of genetic variants in the gene that encodes the molecular motor protein nonmuscle myosin 2a (MYH9) with ESRD in African American patients without diabetes. These new data demonstrate that much of the excess risk of ESRD in African...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18923054
DOI: 10.1681/ASN.2008060621

Genes

MYH9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypertension-associated kidney disease: perhaps no more.PMID 18923054Read ↗

Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African AmericansSemantic proximity Read ↗

Novel findings and future directions on the genetics of hypertension.Semantic proximity Read ↗

Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD.Semantic proximity Read ↗

Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans.Semantic proximity Read ↗

Genetic susceptibility of hypertension-induced kidney disease.Semantic proximity Read ↗

The spectrum of MYH9-associated nephropathy.Semantic proximity Read ↗

MYH9 genetic variants associated with glomerular disease: what is the role for genetic testing?Semantic proximity Read ↗

Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with albuminuria in hypertensive African Americans: the HyperGEN study.Semantic proximity Read ↗

Apolipoprotein L1 gene variants associate with hypertension-attributed nephropathy and the rate of kidney function decline in African Americans.Semantic proximity Read ↗

CKD in MYH9-related disorders.Semantic proximity Read ↗

Hypertension and chronic kidney disease: controversies in pathogenesis and treatment.Semantic proximity Read ↗

Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene.Semantic proximity Read ↗

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