Cytodifferentiation of mouse mammary epithelial cells cultured on a reconstituted basement membrane reveals striking similarities to development in vivo.

doi:10.1242/jcs.99.2.407

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Article

Cytodifferentiation of mouse mammary epithelial cells cultured on a reconstituted basement membrane reveals striking similarities to development in vivo.

Journal of cell science - 1 Jun 1991

Aggeler J, Ward J, Blackie L M, Barcellos-Hoff M H, Streuli C H, Bissell M J

Abstract excerpt

In the present study we provide evidence that the cytodifferentiation of primary mouse mammary epithelial cells within the alveolar-like structures formed after culture on a reconstituted basement membrane resembles development in vivo during late pregnancy and early lactation. During the first two days in culture on a basement membrane gel in the presence of lactogenic hormones, epithelial cells isolated from...

Topics

Animals
Basement Membrane
Caseins
Cell Differentiation
Cell Division
Cells, Cultured
Epithelial Cells
Epithelium
Female
Fluorescent Antibody Technique
Lactation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mammary Glands, Animal

Mice

Microscopy, Electron

Milk Proteins

Phenotype

Pregnancy

Source

Open in PubMed

Identifiers

PMID: 1885677
DOI: 10.1242/jcs.99.2.407

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1885677-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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