Article
Development of a high-throughput microarray-based resequencing system for neurological disorders and its application to molecular genetics of amyotrophic lateral sclerosis.
Archives of neurology - 1 Oct 2008
Takahashi Yuji, Seki Naomi, Ishiura Hiroyuki, Mitsui Jun, Matsukawa Takashi, Kishino Atsushi, Onodera Osamu, Aoki Masashi, Shimozawa Nobuyuki, Murayama Shigeo, Itoyama Yasuto, Suzuki Yasuyuki, Sobue Gen, Nishizawa Masatoyo, Goto Jun, Tsuji Shoji
Abstract excerpt
BACKGROUND: Comprehensive resequencing of the causative and disease-related genes of neurodegenerative diseases is expected to enable (1) comprehensive mutational analysis of familial cases, (2) identification of sporadic cases with de novo or low-penetrant mutations, (3) identification of rare variants conferring disease susceptibility, and ultimately (4) better understanding of the molecular basis of these...
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