Article
Trypanosoma cruzi: Genetic diversity influences the profile of immunoglobulins during experimental infection.
Experimental parasitology - 1 Jan 2009
dos Santos Daniela Maria, Talvani André, Guedes Paulo Marcos da Mata, Machado-Coelho George Luiz Lins, de Lana Marta, Bahia Maria Terezinha
Abstract excerpt
The clonal evolution model postulated for Trypanosoma cruzi predicts a correlation between the phylogenetic divergence of T. cruzi clonal genotypes and their biological properties. In the present study, the linkage between phylogenetic divergence of the parasite and IgG, IgG1, IgG2a and IgG2b response has been evaluated during the acute and chronic phases of the experimental infection. Eight laboratory-cloned...
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