Article
Skeletal muscle differentiation of embryonic mesoangioblasts requires pax3 activity.
Stem cells (Dayton, Ohio) - 1 Jan 2009
Messina Graziella, Sirabella Dario, Monteverde Stefania, Galvez Beatriz G, Tonlorenzi Rossana, Schnapp Esther, De Angelis Luciana, Brunelli Silvia, Relaix Frederic, Buckingham Margaret, Cossu Giulio
Abstract excerpt
Mesoangioblasts have been characterized as a population of vessel-associated stem cells able to differentiate into several mesodermal cell types, including skeletal muscle. Here, we report that the paired box transcription factor Pax3 plays a crucial role in directing mouse mesoangioblasts toward skeletal myogenesis in vitro and in vivo. Mesoangioblasts isolated from the aorta of Pax3 null embryos are severely...
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