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Article

Adiponectin differentially affects gene expression in human mammary epithelial and breast cancer cells

30 Sept 2008

Abstract excerpt

Serum levels of adiponectin are inversely associated with breast cancer risk. In this study, its effect on growth and gene expression of MCF-7 breast cancer cells and MCF-10A human mammary epithelial cells was compared. The antiproliferative effect of adiponectin on MCF-10A cells was more pronounced and was accompanied by elevated transcript levels of caspase 1, ERbeta2, ERbeta5, TR2 and USP2. Our data suggest...

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PMID: 18827813
DOI: 10.1038/sj.bjc.6604692

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