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Article

Chromosome 3 Intratumor Heterogeneity in Uveal Melanoma

26 Jan 2009

Abstract excerpt

PURPOSE: To investigate the presence of focal or diffuse heterogeneity of monosomy 3 in uveal melanoma, by using fluorescence in situ hybridization (FISH). METHODS: Direct interphase FISH in a series of 151 uveal melanomas revealed 82 tumors with loss of chromosome 3. Tumors with monosomy 3 were suspected to be heterogeneous if there were low percentages of monosomy 3, triploid clones, inconsistencies between...

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PMID: 18824727
DOI: 10.1167/iovs.08-2279

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