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Characterization of Two <i>Campylobacter jejuni</i> Strains for Use in Volunteer Experimental-Infection Studies

23 Sept 2008

Abstract excerpt

The development of vaccines against Campylobacter jejuni would be facilitated by the ability to perform phase II challenge studies. However, molecular mimicry of the lipooligosaccharide (LOS) of most C. jejuni strains with human gangliosides presents safety concerns about the development of Guillain-Barré syndrome. Clinical isolates of C. jejuni that appeared to lack genes for the synthesis of ganglioside mimics...

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PMID: 18809665
DOI: 10.1128/iai.00780-08

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