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Article

Evolution of the inflammatory response in vertebrates: fish TNF-alpha is a powerful activator of endothelial cells but hardly activates phagocytes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2008

Roca Francisco J, Mulero Iván, López-Muñoz Azucena, Sepulcre Maria P, Renshaw Stephen A, Meseguer José, Mulero Victoriano

Abstract excerpt

TNF-alpha is conserved in all vertebrate classes and has been identified in all taxonomic groups of teleost fish. However, its biological activities and its role in infection are largely unknown. Using two complementary fish models, gilthead seabream and zebrafish, we report here that the main pr...

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PMID: 18802111
DOI: 10.4049/jimmunol.181.7.5071

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18802111-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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