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Article

Cinnamaldehyde and cinnamaldehyde derivatives reduce virulence in Vibrio spp. by decreasing the DNA-binding activity of the quorum sensing response regulator LuxR.

BMC microbiology - 16 Sept 2008

Brackman Gilles, Defoirdt Tom, Miyamoto Carol, Bossier Peter, Van Calenbergh Serge, Nelis Hans, Coenye Tom

Abstract excerpt

BACKGROUND: To date, only few compounds targeting the AI-2 based quorum sensing (QS) system are known. In the present study, we screened cinnamaldehyde and substituted cinnamaldehydes for their ability to interfere with AI-2 based QS. The mechanism of QS inhibition was elucidated by measuring the effect on bioluminescence in several Vibrio harveyi mutants. We also studied in vitro the ability of these compounds...

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Identifiers

PMID: 18793453
DOI: 10.1186/1471-2180-8-149
PMCID: PMC2551610

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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