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Article

Overexpression of progesterone receptor B increases sensitivity of human colon muscle cells to progesterone.

American journal of physiology. Gastrointestinal and liver physiology - 1 Sept 2008

Cheng Ling, Pricolo Victor, Biancani Piero, Behar Jose

Abstract excerpt

Colon muscle strips and cells from female patients with slow-transit constipation (STC) exhibit impaired motility, signal transduction abnormalities characterized by downregulation of Gq/11 and upregulation of Gs proteins, decreased cyclooxygenase (COX)-1 and thromboxane (Tx)B2 levels, increased COX-2 and PGE2 levels, and overexpression of progesterone receptors (PGR). Progesterone (P4) treatment of normal cells...

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Share to Calmodulin-Binding Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18776045
DOI: 10.1152/ajpgi.90214.2008
PMCID: PMC2536785

Genes

PGR
CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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