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Targeting Hsp90 prevents escape of breast cancer cells from tyrosine kinase inhibition

15 Sept 2008

Abstract excerpt

Recent studies have identified development of resistance to tyrosine kinase inhibition (TKI) as a significant roadblock to effective treatment. One mechanism of resistance recently appreciated involves 'oncogene switching', or the re-activation of signaling pathways by one or more redundant upstream activators. In breast cancer models, ErbB TKIs such as gefitinib have been shown to lose the ability to modulate...

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PMID: 18769157
DOI: 10.4161/cc.7.18.6701

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