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Article

Dynamic CpG methylation of the KCNQ1OT1 gene during maturation of human oocytes

1 Sept 2008

Abstract excerpt

BACKGROUND: Imprinted genes, many of which are involved in development, are marked during gametogenesis to allow their parent-of-origin specific expression, and DNA methylation at CpG islands is part of this epigenetic mark. Maternal imprint is apposed on oocyte during growth and maturation. Factors interfering with normal oocyte differentiation such as gonadotrophin stimulation and in vitro maturation (IVM) may...

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Share to Epigenetics and DNA Methylation
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PMID: 18762571
DOI: 10.1136/jmg.2008.057943

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