Article
Mutations M184V and Y115F in HIV-1 reverse transcriptase discriminate against "nucleotide-competing reverse transcriptase inhibitors".
The Journal of biological chemistry - 31 Oct 2008
Ehteshami Maryam, Scarth Brian J, Tchesnokov Egor P, Dash Chandravanu, Le Grice Stuart F J, Hallenberger Sabine, Jochmans Dirk, Götte Matthias
Abstract excerpt
Indolopyridones are potent inhibitors of reverse transcriptase (RT) of the human immunodeficiency virus type 1 (HIV-1). Although the structure of these compounds differs from established nucleoside analogue RT inhibitors (NRTIs), previous studies suggest that the prototype compound INDOPY-1 may bind in close proximity to the polymerase active site. NRTI-associated mutations that are clustered around the active...
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