Article
Is 60 days of ciprofloxacin administration necessary for postexposure prophylaxis for Bacillus anthracis?
Antimicrobial agents and chemotherapy - 1 Nov 2008
Drusano G L, Okusanya Olanrewaju O, Okusanya Adedoyin, Van Scoy Brian, Brown D L, Kulawy Robert, Sörgel Fritz, Heine Henry S, Louie Arnold
Abstract excerpt
Sixty days of ciprofloxacin administration at 500 mg every 12 h is currently recommended for the prophylaxis of inhalational exposure to Bacillus anthracis. We examined Bacillus anthracis (Delta-Sterne strain) in our hollow-fiber infection model. We measured the ciprofloxacin concentrations achieved and the number of organisms present before heat shock (total population) and after heat shock (spore population)....
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