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Article

Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease.

Circulation research - 26 Sept 2008

Stankunas Kryn, Shang Ching, Twu Karen Y, Kao Shih-Chu, Jenkins Nancy A, Copeland Neal G, Sanyal Mrinmoy, Selleri Licia, Cleary Michael L, Chang Ching-Pin

Abstract excerpt

Congenital heart diseases are traditionally considered to be multifactorial in pathogenesis resulting from environmental and genetic interactions that determine penetrance and expressivity within a genetically predisposed family. Recent evidence suggests that genetic contributions have been significantly underestimated. However, single gene defects occur only in a minority of cases, and multigenetic causes of...

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Identifiers

PMID: 18723445
DOI: 10.1161/CIRCRESAHA.108.175489
PMCID: PMC2633052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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