Article
High frequency of submicroscopic genomic aberrations detected by tiling path array comparative genome hybridisation in patients with isolated congenital heart disease.
Journal of medical genetics - 1 Nov 2008
Erdogan F, Larsen L A, Zhang L, Tümer Z, Tommerup N, Chen W, Jacobsen J R, Schubert M, Jurkatis J, Tzschach A, Ropers H-H, Ullmann R
Abstract excerpt
BACKGROUND: Congenital heart disease (CHD) is the most common birth defect and affects nearly 1% of newborns. The aetiology of CHD is largely unknown and only a small percentage can be assigned to environmental risk factors such as maternal diseases or exposure to mutagenic agents during pregnancy. Chromosomal imbalances have been identified in many forms of syndromic CHD, but very little is known about the...
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