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Article

A method for genotype validation and primer assessment in heterozygote-deficient species, as demonstrated in the prosobranch mollusc Hydrobia ulvae.

BMC genetics - 19 Aug 2008

Brownlow Robert J, Dawson Deborah A, Horsburgh Gavin J, Bell James J, Fish John D

Abstract excerpt

BACKGROUND: In studies where microsatellite markers are employed, it is essential that the primers designed will reliably and consistently amplify target loci. In populations conforming to Hardy-Weinberg equilibrium (HWE), screening for unreliable markers often relies on the identification of heterozygote deficiencies and subsequent departures from HWE. However, since many populations naturally deviate from HWE,...

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PMID: 18713472
DOI: 10.1186/1471-2156-9-55
PMCID: PMC2536670

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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